Rebooting the Immune System

A sign rests on the windowsill in the office of Jeffrey Bluestone, director of the Immune Tolerance Network and the Diabetes Center at the University of California at San Francisco. Measuring nearly three feet across, it reads “Club Bluestone” in pink and blue neon. It’s the sort of artifact you’d expect to find in a bar. But Bluestone is a world-renowned immunobiologist; his father-in-law had the sign made for him in the late 1980s when Bluestone was working long hours in his lab at the University of Chicago. As the night wore on and their energy faded, he and his colleagues would turn out the lights, turn on the sign and, propelled by the power of Bruce Springsteen, push forward with their research. “It was our version of partying,” he says.

As you may already know, auto-immune diseases like Type 1 diabetes or multiple sclerosis occur when your immune system malfunctions and mistakes part of your own body for a foreign invader. In the case of Type 1, it's when your body decides to kill off the cells that produce insulin, a hormone necessary to absorb the energy in your food. I think I speak for all Type 1 diabetics when I say that destroying these cells is not the body's smartest move.

I was lucky enough to participate in a trial for a promising new drug -- created by the aforementioned Jeffrey Bluestone -- that attempted to stop my system from killing off the rest of my insulin-producing cells. What's more, I recently got a chance to write about this drug -- and others like it -- for Popular Science. The article's called "Rebooting the Body." Here's a link to a digital copy.

I also got a chance to speak about the piece on the New Hampshire Public Radio Show, Word of Mouth. You can listen to the interview here.